diff --git a/autotest.sh b/autotest.sh
index d7b6922df..314e238c8 100755
--- a/autotest.sh
+++ b/autotest.sh
@@ -176,9 +176,12 @@ if [ $SPDK_RUN_FUNCTIONAL_TEST -eq 1 ]; then
 
 	if [ $SPDK_TEST_NVME -eq 1 ]; then
 		run_test suite test/nvme/nvme.sh
-		if [ $SPDK_TEST_NVME_CLI -eq 1 ]; then
+		if [[ $SPDK_TEST_NVME_CLI -eq 1 ]]; then
 			run_test suite test/nvme/spdk_nvme_cli.sh
 		fi
+		if [[ $SPDK_TEST_NVME_CUSE -eq 1 ]]; then
+			run_test suite test/nvme/spdk_nvme_cli_cuse.sh
+		fi
 		# Only test hotplug without ASAN enabled. Since if it is
 		# enabled, it catches SEGV earlier than our handler which
 		# breaks the hotplug logic.
diff --git a/test/common/autotest_common.sh b/test/common/autotest_common.sh
index d3338b91e..c28a376cb 100644
--- a/test/common/autotest_common.sh
+++ b/test/common/autotest_common.sh
@@ -39,6 +39,7 @@ export RUN_NIGHTLY_FAILING
 : ${SPDK_TEST_ISCSI_INITIATOR=0}; export SPDK_TEST_ISCSI_INITIATOR
 : ${SPDK_TEST_NVME=0}; export SPDK_TEST_NVME
 : ${SPDK_TEST_NVME_CLI=0}; export SPDK_TEST_NVME_CLI
+: ${SPDK_TEST_NVME_CUSE=0}; export SPDK_TEST_NVME_CUSE
 : ${SPDK_TEST_NVMF=0}; export SPDK_TEST_NVMF
 : ${SPDK_TEST_NVMF_TRANSPORT="rdma"}; export SPDK_TEST_NVMF_TRANSPORT
 : ${SPDK_TEST_RBD=0}; export SPDK_TEST_RBD
@@ -162,6 +163,10 @@ if [ -d /usr/include/iscsi ]; then
 	fi
 fi
 
+if [ $SPDK_TEST_NVME_CUSE -eq 1 ]; then
+	config_params+=' --with-nvme-cuse'
+fi
+
 # for options with both dependencies and a test flag, set them here
 if [ -f /usr/include/libpmemblk.h ] && [ $SPDK_TEST_PMDK -eq 1 ]; then
 	config_params+=' --with-pmdk'
diff --git a/test/nvme/spdk_nvme_cli_cuse.sh b/test/nvme/spdk_nvme_cli_cuse.sh
new file mode 100755
index 000000000..f75d5076e
--- /dev/null
+++ b/test/nvme/spdk_nvme_cli_cuse.sh
@@ -0,0 +1,50 @@
+#!/usr/bin/env bash
+
+testdir=$(readlink -f $(dirname $0))
+rootdir=$(readlink -f $testdir/../..)
+source $rootdir/scripts/common.sh
+source $rootdir/test/common/autotest_common.sh
+
+timing_enter nvme_cli_cuse
+
+NVME_CMD=/usr/local/src/nvme-cli/nvme
+rpc_py=$rootdir/scripts/rpc.py
+
+$rootdir/app/spdk_tgt/spdk_tgt -m 0x3 &
+spdk_tgt_pid=$!
+trap 'kill -9 ${spdk_tgt_pid}; exit 1' SIGINT SIGTERM EXIT
+
+waitforlisten $spdk_tgt_pid
+
+bdf=$(iter_pci_class_code 01 08 02 | head -1)
+
+$rpc_py bdev_nvme_attach_controller -b Nvme0 -t PCIe -a ${bdf}
+$rpc_py bdev_nvme_cuse_register -n Nvme0 -p spdk/nvme0
+
+sleep 5
+
+$rpc_py bdev_get_bdevs
+$rpc_py bdev_nvme_get_controllers
+
+for ns in $(ls /dev/spdk/nvme?n?); do
+	${NVME_CMD} get-ns-id $ns
+	${NVME_CMD} id-ns $ns
+	${NVME_CMD} list-ns $ns
+done
+
+for ctrlr in $(ls /dev/spdk/nvme?); do
+	${NVME_CMD} id-ctrl $ctrlr
+	${NVME_CMD} list-ctrl $ctrlr
+	${NVME_CMD} fw-log $ctrlr
+	${NVME_CMD} smart-log $ctrlr
+	${NVME_CMD} error-log $ctrlr
+	${NVME_CMD} get-feature $ctrlr -f 1 -s 1 -l 100
+	${NVME_CMD} get-log $ctrlr -i 1 -l 100
+	${NVME_CMD} reset $ctrlr
+done
+
+trap - SIGINT SIGTERM EXIT
+kill $spdk_tgt_pid
+
+report_test_completion spdk_nvme_cli_cuse
+timing_exit nvme_cli_cuse