diff --git a/autotest.sh b/autotest.sh
index 6434deef4..a1eb48b1b 100755
--- a/autotest.sh
+++ b/autotest.sh
@@ -92,7 +92,12 @@ fi
 
 if [ $SPDK_TEST_NVME -eq 1 ]; then
 	run_test test/lib/nvme/nvme.sh
-	run_test test/lib/nvme/hotplug.sh intel
+	# Only test hotplug without ASAN enabled. Since if it is
+	# enabled, it catches SEGV earlier than our handler which
+	# breaks the hotplug logic
+	if [ $SPDK_RUN_ASAN -eq 0 ]; then
+		run_test test/lib/nvme/hotplug.sh intel
+	fi
 	if [ $RUN_NIGHTLY -eq 1 ]; then
 		run_test test/lib/nvme/nvmemp.sh
 	fi
diff --git a/scripts/autotest_common.sh b/scripts/autotest_common.sh
index 9a6ea4141..8b698ee37 100755
--- a/scripts/autotest_common.sh
+++ b/scripts/autotest_common.sh
@@ -23,6 +23,7 @@ fi
 : ${SPDK_TEST_IOAT=1}; export SPDK_TEST_IOAT
 : ${SPDK_TEST_EVENT=1}; export SPDK_TEST_EVENT
 : ${SPDK_TEST_BLOBFS=1}; export SPDK_TEST_BLOBFS
+: ${SPDK_RUN_ASAN=0}; export SPDK_RUN_ASAN
 
 config_params='--enable-debug --enable-werror'
 
@@ -49,6 +50,13 @@ case `uname` in
 		MAKEFLAGS=${MAKEFLAGS:--j$(nproc)}
 		config_params+=' --enable-coverage'
 		config_params+=' --enable-ubsan'
+		if [ $SPDK_RUN_ASAN -eq 1 ]; then
+			if /usr/sbin/ldconfig -p | grep -q asan; then
+				config_params+=' --enable-asan'
+			else
+				SPDK_RUN_ASAN=0
+			fi
+		fi
 		;;
 	*)
 		echo "Unknown OS in $0"
@@ -86,7 +94,8 @@ if [ -z "$output_dir" ]; then
 	export output_dir
 fi
 
-if [ $SPDK_RUN_VALGRIND -eq 1 ] && hash valgrind &> /dev/null; then
+# Valgrind does not work well when ASAN is enabled, so only use valgrind if ASAN is disabled
+if [ $SPDK_RUN_ASAN -eq 0 ] && [ $SPDK_RUN_VALGRIND -eq 1 ] && hash valgrind &> /dev/null; then
 	valgrind='valgrind --leak-check=full --error-exitcode=2'
 else
 	valgrind=''
diff --git a/test/lib/nvme/nvme.sh b/test/lib/nvme/nvme.sh
index a52905f99..8a708498d 100755
--- a/test/lib/nvme/nvme.sh
+++ b/test/lib/nvme/nvme.sh
@@ -71,7 +71,10 @@ PLUGIN_DIR=$rootdir/examples/nvme/fio_plugin
 if [ -d /usr/src/fio ]; then
 	timing_enter fio_plugin
 	for bdf in $(linux_iter_pci 0108); do
-		LD_PRELOAD=$PLUGIN_DIR/fio_plugin /usr/src/fio/fio $PLUGIN_DIR/example_config.fio --filename="trtype=PCIe traddr=${bdf//:/.} ns=1"
+		# Only test when ASAN is not enabled. If ASAN is enabled, we cannot test.
+		if [ $SPDK_RUN_ASAN -eq 0 ]; then
+			LD_PRELOAD=$PLUGIN_DIR/fio_plugin /usr/src/fio/fio $PLUGIN_DIR/example_config.fio --filename="trtype=PCIe traddr=${bdf//:/.} ns=1"
+		fi
 		break
 	done