diff --git a/doc/Doxyfile b/doc/Doxyfile
index 53a62713b..62c5dd194 100644
--- a/doc/Doxyfile
+++ b/doc/Doxyfile
@@ -834,6 +834,7 @@ INPUT                  += \
                          nvmf.md \
                          nvmf_tgt_pg.md \
                          nvmf_tracing.md \
+                         nvmf_multipath_howto.md \
                          overview.md \
                          peer_2_peer.md \
                          pkgconfig.md \
diff --git a/doc/nvmf.md b/doc/nvmf.md
index b19fff19c..1a4346e0d 100644
--- a/doc/nvmf.md
+++ b/doc/nvmf.md
@@ -270,3 +270,8 @@ nvme disconnect -n "nqn.2016-06.io.spdk:cnode1"
 
 SPDK has a tracing framework for capturing low-level event information at runtime.
 @ref nvmf_tgt_tracepoints enable analysis of both performance and application crashes.
+
+## Enabling NVMe-oF Multipath
+
+The SPDK NVMe-oF target and initiator support multiple independent paths to the same NVMe-oF subsystem.
+For step-by-step instructions for configuring and switching between paths, see @ref nvmf_multipath_howto .
diff --git a/doc/nvmf_multipath_howto.md b/doc/nvmf_multipath_howto.md
new file mode 100644
index 000000000..9aabb51c6
--- /dev/null
+++ b/doc/nvmf_multipath_howto.md
@@ -0,0 +1,104 @@
+# NVMe-oF Multipath HOWTO {#nvmf_multipath_howto}
+
+This HOWTO provides step-by-step instructions for setting-up a simple SPDK deployment and testing multipath.
+It demonstrates configuring path preferences with Asymmetric Namespace Access (ANA), as well as round-robin
+path load balancing.
+
+## Build SPDK on both the initiator and target servers
+
+Clone the repo:
+~~~{.sh}
+git clone https://github.com/spdk/spdk
+~~~
+
+Configure and build SPDK:
+~~~{.sh}
+cd spdk/
+git submodule update --init
+./configure
+make -j16
+~~~
+
+## Setup hugepages
+
+This should be run once on each server (and after reboots):
+~~~{.sh}
+cd spdk/
+./scripts/setup.sh
+~~~
+
+## On target: start and configure SPDK
+
+Start the target in the background and configure it:
+~~~{.sh}
+cd spdk/
+./build/bin/nvmf_tgt -m 0x3 &
+./scripts/rpc.py nvmf_create_transport -t tcp -o -u 8192
+~~~
+
+Create a subsystem, with `-r` to enable ANA reporting feature:
+~~~{.sh}
+./scripts/rpc.py nvmf_create_subsystem nqn.2022-02.io.spdk:cnode0 -a -s SPDK00000000000001 -r
+~~~
+
+Create and add a malloc block device:
+~~~{.sh}
+./scripts/rpc.py bdev_malloc_create 64 512 -b Malloc0
+./scripts/rpc.py nvmf_subsystem_add_ns nqn.2022-02.io.spdk:cnode0 Malloc0
+~~~
+
+Add two listeners, each with a different `IP:port` pair:
+~~~{.sh}
+./scripts/rpc.py nvmf_subsystem_add_listener -t tcp -a 172.17.1.13 -s 4420 nqn.2022-02.io.spdk:cnode0
+./scripts/rpc.py nvmf_subsystem_add_listener -t tcp -a 172.18.1.13 -s 5520 nqn.2022-02.io.spdk:cnode0
+~~~
+
+## On initiator: start and configure bdevperf
+
+Launch the bdevperf process in the background:
+~~~{.sh}
+cd spdk/
+./test/bdev/bdevperf/bdevperf -m 0x4 -z -r /tmp/bdevperf.sock -q 128 -o 4096 -w verify -t 90 &> bdevperf.log &
+~~~
+
+Configure bdevperf and add two paths:
+~~~{.sh}
+./scripts/rpc.py -s /tmp/bdevperf.sock bdev_nvme_set_options -r -1
+./scripts/rpc.py -s /tmp/bdevperf.sock bdev_nvme_attach_controller -b Nvme0 -t tcp -a 172.17.1.13 -s 4420 -f ipv4 -n nqn.2022-02.io.spdk:cnode0 -l -1 -o 10
+./scripts/rpc.py -s /tmp/bdevperf.sock bdev_nvme_attach_controller -b Nvme0 -t tcp -a 172.18.1.13 -s 5520 -f ipv4 -n nqn.2022-02.io.spdk:cnode0 -x multipath -l -1 -o 10
+~~~
+
+## Launch a bdevperf test
+
+Connect to the RPC socket of the bdevperf process and start the test:
+~~~{.sh}
+PYTHONPATH=$PYTHONPATH:/root/src/spdk/python ./test/bdev/bdevperf/bdevperf.py -t 1 -s /tmp/bdevperf.sock perform_tests
+~~~
+
+The RPC command will return, leaving the test to run for 90 seconds in the background. On the target server,
+observe that only the first path (port) is receiving packets by checking the queues with `ss -t`.
+
+You can view the paths available to the initiator with:
+~~~{.sh}
+./scripts/rpc.py -s /tmp/bdevperf.sock bdev_nvme_get_io_paths -n Nvme0n1
+~~~
+
+## Switching paths
+
+This can be done on the target server by setting the first path's ANA to `non_optimized`:
+~~~{.sh}
+./scripts/rpc.py nvmf_subsystem_listener_set_ana_state nqn.2022-02.io.spdk:cnode0 -t tcp -a 172.17.1.13 -s 4420 -n non_optimized
+~~~
+
+Use `ss -t`  to verify that the traffic has switched to the second path.
+
+## Use round-robin (active_active) path load balancing
+
+First, ensure the ANA for both paths is configured as `optimized` on the target. Then, change the
+multipath policy on the initiator to `active_active` (multipath policy is per bdev, so
+`bdev_nvme_set_multipath_policy` must be called after `bdev_nvme_attach_controller`):
+~~~{.sh}
+./scripts/rpc.py -s /tmp/bdevperf.sock bdev_nvme_set_multipath_policy -b Nvme0n1 -p active_active
+~~~
+
+Observe with `ss -t` that both connections are receiving traffic (queues build up).