diff --git a/CONFIG b/CONFIG
index 97a8244f4..6aa76e7e3 100644
--- a/CONFIG
+++ b/CONFIG
@@ -3,6 +3,7 @@
 #
 #  Copyright (c) Intel Corporation.
 #  All rights reserved.
+#  Copyright (c) 2021 NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 #
 #  Redistribution and use in source and binary forms, with or without
 #  modification, are permitted provided that the following conditions
@@ -141,6 +142,9 @@ CONFIG_PMDK_DIR=
 # Enable the dependencies for building the compress vbdev
 CONFIG_REDUCE=n
 
+# Enable mlx5_pci dpdk compress PMD, enabled automatically if CONFIG_REDUCE=y and libmlx5 exists
+CONFIG_REDUCE_MLX5=n
+
 # Requires libiscsi development libraries.
 CONFIG_ISCSI_INITIATOR=n
 
diff --git a/configure b/configure
index e734e1326..def3e85ca 100755
--- a/configure
+++ b/configure
@@ -733,6 +733,15 @@ if [[ "${CONFIG[REDUCE]}" = "y" ]]; then
 		echo "Please install then re-run this script."
 		exit 1
 	fi
+
+	if echo -e '#include <spdk/stdinc.h>\n' \
+		'#include <infiniband/mlx5dv.h>\n' \
+		'#include <infiniband/verbs.h>\n' \
+		'int main(void) { return 0; }\n' \
+		| "${BUILD_CMD[@]}" -lmlx5 -I${rootdir}/include -c - 2> /dev/null; then
+		CONFIG[REDUCE_MLX5]="y"
+		echo "mlx5 available so enabling DPDK mlx5_pci compress PMD"
+	fi
 fi
 
 if [[ "${CONFIG[NVME_CUSE]}" = "y" ]]; then
diff --git a/dpdkbuild/Makefile b/dpdkbuild/Makefile
index d4af3a0a4..5c6b4facf 100644
--- a/dpdkbuild/Makefile
+++ b/dpdkbuild/Makefile
@@ -3,6 +3,7 @@
 #
 #  Copyright (c) Intel Corporation.
 #  All rights reserved.
+#  Copyright (c) 2021 NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 #
 #  Redistribution and use in source and binary forms, with or without
 #  modification, are permitted provided that the following conditions
@@ -66,6 +67,9 @@ endif
 
 ifeq ($(CONFIG_REDUCE),y)
 DPDK_DRIVERS += compress compress/isal
+ifeq ($(CONFIG_REDUCE_MLX5),y)
+DPDK_DRIVERS += common/mlx5 compress/mlx5
+endif
 DPDK_CFLAGS += -I$(ISAL_DIR)
 DPDK_LDFLAGS += -L$(ISAL_DIR)/.libs -lisal
 endif
diff --git a/lib/env_dpdk/env.mk b/lib/env_dpdk/env.mk
index 7d256e06f..3ff5a7db6 100644
--- a/lib/env_dpdk/env.mk
+++ b/lib/env_dpdk/env.mk
@@ -3,6 +3,7 @@
 #
 #  Copyright (c) Intel Corporation.
 #  All rights reserved.
+#  Copyright (c) 2021 NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 #
 #  Redistribution and use in source and binary forms, with or without
 #  modification, are permitted provided that the following conditions
@@ -93,6 +94,9 @@ else
 # PMD name for DPDK 20.08 and earlier
 DPDK_LIB_LIST += rte_pmd_isal
 endif
+ifeq ($(CONFIG_REDUCE_MLX5),y)
+DPDK_LIB_LIST += rte_common_mlx5 rte_compress_mlx5
+endif
 endif
 
 ifeq ($(DPDK_FRAMEWORK),y)
@@ -146,6 +150,9 @@ endif
 
 ifeq ($(CONFIG_REDUCE),y)
 DPDK_PRIVATE_LINKER_ARGS += -lisal -L$(ISAL_DIR)/.libs
+ifeq ($(CONFIG_REDUCE_MLX5),y)
+DPDK_PRIVATE_LINKER_ARGS += -lmlx5
+endif
 endif
 
 ifneq (,$(wildcard $(DPDK_INC_DIR)/rte_config.h))
diff --git a/mk/spdk.modules.mk b/mk/spdk.modules.mk
index 415a3b2d7..db177d81f 100644
--- a/mk/spdk.modules.mk
+++ b/mk/spdk.modules.mk
@@ -3,6 +3,7 @@
 #
 #  Copyright (c) Intel Corporation.
 #  All rights reserved.
+#  Copyright (c) 2021 NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 #
 #  Redistribution and use in source and binary forms, with or without
 #  modification, are permitted provided that the following conditions
@@ -57,6 +58,9 @@ endif
 ifeq ($(CONFIG_REDUCE),y)
 BLOCKDEV_MODULES_LIST += bdev_compress reduce
 BLOCKDEV_MODULES_PRIVATE_LIBS += -lpmem
+ifeq ($(CONFIG_REDUCE_MLX5),y)
+BLOCKDEV_MODULES_PRIVATE_LIBS += -lmlx5
+endif
 endif
 
 ifeq ($(CONFIG_RDMA),y)