diff --git a/autotest.sh b/autotest.sh
index 3ca78a6a1..5f0d4f7ca 100755
--- a/autotest.sh
+++ b/autotest.sh
@@ -153,6 +153,11 @@ rdma_device_init
 timing_exit nvmf_setup
 
 if [[ $SPDK_TEST_CRYPTO -eq 1 || $SPDK_TEST_REDUCE -eq 1 ]]; then
+	# Make sure that memory is distributed across all NUMA nodes - by default, all goes to
+	# node0, but if QAT devices are attached to a different node, all of their VFs will end
+	# up under that node too and memory needs to be available there for the tests.
+	CLEAR_HUGE=yes HUGE_EVEN_ALLOC=yes ./scripts/setup.sh
+	./scripts/setup.sh status
 	if grep -q '#define SPDK_CONFIG_IGB_UIO_DRIVER 1' $rootdir/include/spdk/config.h; then
 		./scripts/qat_setup.sh igb_uio
 	else