diff --git a/include/spdk/accel.h b/include/spdk/accel.h
index a8ee8af81..052e4afb1 100644
--- a/include/spdk/accel.h
+++ b/include/spdk/accel.h
@@ -381,6 +381,81 @@ int spdk_accel_append_decompress(struct spdk_accel_sequence **seq, struct spdk_i
 				 struct spdk_memory_domain *src_domain, void *src_domain_ctx,
 				 int flags, spdk_accel_step_cb cb_fn, void *cb_arg);
 
+/**
+ * Append an encrypt operation to a sequence.
+ *
+ * `nbytes` must be multiple of `block_size`.  `iv` is used to encrypt the first logical block of
+ * size `block_size`.  If `src_iovs` describes more than one logical block then `iv` will be
+ * incremented for each next logical block.  Data Encryption Key identifier should be created before
+ * calling this function using methods specific to the accel module being used.
+ *
+ * \param seq Sequence object.  If NULL, a new sequence object will be created.
+ * \param ch I/O channel.
+ * \param key Data Encryption Key identifier
+ * \param dst_iovs Destination I/O vector array.
+ * \param dst_iovcnt Size of the `dst_iovs` array.
+ * \param dst_domain Memory domain to which the destination buffers belong.
+ * \param dst_domain_ctx Destination buffer domain context.
+ * \param src_iovs Source I/O vector array.
+ * \param src_iovcnt Size of the `src_iovs` array.
+ * \param src_domain Memory domain to which the source buffers belong.
+ * \param src_domain_ctx Source buffer domain context.
+ * \param iv Initialization vector (tweak) used for encryption
+ * \param block_size Logical block size, if src contains more than 1 logical block, subsequent
+ *        logical blocks will be encrypted with incremented `iv`.
+ * \param flags Accel operation flags.
+ * \param cb_fn Callback to be executed once this operation is completed.
+ * \param cb_arg Argument to be passed to `cb_fn`.
+ *
+ * \return 0 if operation was successfully added to the sequence, negative errno otherwise.
+ */
+int spdk_accel_append_encrypt(struct spdk_accel_sequence **seq, struct spdk_io_channel *ch,
+			      struct spdk_accel_crypto_key *key,
+			      struct iovec *dst_iovs, uint32_t dst_iovcnt,
+			      struct spdk_memory_domain *dst_domain, void *dst_domain_ctx,
+			      struct iovec *src_iovs, uint32_t src_iovcnt,
+			      struct spdk_memory_domain *src_domain, void *src_domain_ctx,
+			      uint64_t iv, uint32_t block_size, int flags,
+			      spdk_accel_step_cb cb_fn, void *cb_arg);
+
+/**
+ * Append a decrypt operation to a sequence.
+ *
+ * `nbytes` must be multiple of `block_size`. `iv` is used to decrypt the first logical block of
+ * size `block_size`. If `src_iovs` describes more than one logical block then `iv` will be
+ * incremented for each next logical block.  Data Encryption Key identifier should be created before
+ * calling this function using methods specific to the accel module being used.
+ *
+ * \param seq Sequence object.  If NULL, a new sequence object will be created.
+ * \param ch I/O channel.
+ * \param key Data Encryption Key identifier
+ * \param dst_iovs Destination I/O vector array.
+ * \param dst_iovcnt Size of the `dst_iovs` array.
+ * \param dst_domain Memory domain to which the destination buffers belong.
+ * \param dst_domain_ctx Destination buffer domain context.
+ * \param src_iovs Source I/O vector array.
+ * \param src_iovcnt Size of the `src_iovs` array.
+ * \param src_domain Memory domain to which the source buffers belong.
+ * \param src_domain_ctx Source buffer domain context.
+ * \param iv Initialization vector (tweak) used for decryption. Should be the same as `iv` used for
+ *        encryption of a data block.
+ * \param block_size Logical block size, if src contains more than 1 logical block, subsequent
+ *        logical blocks will be decrypted with incremented `iv`.
+ * \param flags Accel operation flags.
+ * \param cb_fn Callback to be executed once this operation is completed.
+ * \param cb_arg Argument to be passed to `cb_fn`.
+ *
+ * \return 0 if operation was successfully added to the sequence, negative errno otherwise.
+ */
+int spdk_accel_append_decrypt(struct spdk_accel_sequence **seq, struct spdk_io_channel *ch,
+			      struct spdk_accel_crypto_key *key,
+			      struct iovec *dst_iovs, uint32_t dst_iovcnt,
+			      struct spdk_memory_domain *dst_domain, void *dst_domain_ctx,
+			      struct iovec *src_iovs, uint32_t src_iovcnt,
+			      struct spdk_memory_domain *src_domain, void *src_domain_ctx,
+			      uint64_t iv, uint32_t block_size, int flags,
+			      spdk_accel_step_cb cb_fn, void *cb_arg);
+
 /**
  * Finish a sequence and execute all its operations. After the completion callback is executed, the
  * sequence object is automatically freed.
diff --git a/lib/accel/accel.c b/lib/accel/accel.c
index 9b5a18565..e458d1d5f 100644
--- a/lib/accel/accel.c
+++ b/lib/accel/accel.c
@@ -919,6 +919,118 @@ spdk_accel_append_decompress(struct spdk_accel_sequence **pseq, struct spdk_io_c
 	return 0;
 }
 
+int
+spdk_accel_append_encrypt(struct spdk_accel_sequence **pseq, struct spdk_io_channel *ch,
+			  struct spdk_accel_crypto_key *key,
+			  struct iovec *dst_iovs, uint32_t dst_iovcnt,
+			  struct spdk_memory_domain *dst_domain, void *dst_domain_ctx,
+			  struct iovec *src_iovs, uint32_t src_iovcnt,
+			  struct spdk_memory_domain *src_domain, void *src_domain_ctx,
+			  uint64_t iv, uint32_t block_size, int flags,
+			  spdk_accel_step_cb cb_fn, void *cb_arg)
+{
+	struct accel_io_channel *accel_ch = spdk_io_channel_get_ctx(ch);
+	struct spdk_accel_task *task;
+	struct spdk_accel_sequence *seq = *pseq;
+
+	if (spdk_unlikely(!dst_iovs || !dst_iovcnt || !src_iovs || !src_iovcnt || !key ||
+			  !block_size)) {
+		return -EINVAL;
+	}
+
+	if (seq == NULL) {
+		seq = accel_sequence_get(accel_ch);
+		if (spdk_unlikely(seq == NULL)) {
+			return -ENOMEM;
+		}
+	}
+
+	assert(seq->ch == accel_ch);
+	task = accel_sequence_get_task(accel_ch, seq, cb_fn, cb_arg);
+	if (spdk_unlikely(task == NULL)) {
+		if (*pseq == NULL) {
+			accel_sequence_put(seq);
+		}
+
+		return -ENOMEM;
+	}
+
+	task->crypto_key = key;
+	task->src_domain = src_domain;
+	task->src_domain_ctx = src_domain_ctx;
+	task->s.iovs = src_iovs;
+	task->s.iovcnt = src_iovcnt;
+	task->dst_domain = dst_domain;
+	task->dst_domain_ctx = dst_domain_ctx;
+	task->d.iovs = dst_iovs;
+	task->d.iovcnt = dst_iovcnt;
+	task->iv = iv;
+	task->block_size = block_size;
+	task->flags = flags;
+	task->op_code = ACCEL_OPC_ENCRYPT;
+
+	TAILQ_INSERT_TAIL(&seq->tasks, task, seq_link);
+	*pseq = seq;
+
+	return 0;
+}
+
+int
+spdk_accel_append_decrypt(struct spdk_accel_sequence **pseq, struct spdk_io_channel *ch,
+			  struct spdk_accel_crypto_key *key,
+			  struct iovec *dst_iovs, uint32_t dst_iovcnt,
+			  struct spdk_memory_domain *dst_domain, void *dst_domain_ctx,
+			  struct iovec *src_iovs, uint32_t src_iovcnt,
+			  struct spdk_memory_domain *src_domain, void *src_domain_ctx,
+			  uint64_t iv, uint32_t block_size, int flags,
+			  spdk_accel_step_cb cb_fn, void *cb_arg)
+{
+	struct accel_io_channel *accel_ch = spdk_io_channel_get_ctx(ch);
+	struct spdk_accel_task *task;
+	struct spdk_accel_sequence *seq = *pseq;
+
+	if (spdk_unlikely(!dst_iovs || !dst_iovcnt || !src_iovs || !src_iovcnt || !key ||
+			  !block_size)) {
+		return -EINVAL;
+	}
+
+	if (seq == NULL) {
+		seq = accel_sequence_get(accel_ch);
+		if (spdk_unlikely(seq == NULL)) {
+			return -ENOMEM;
+		}
+	}
+
+	assert(seq->ch == accel_ch);
+	task = accel_sequence_get_task(accel_ch, seq, cb_fn, cb_arg);
+	if (spdk_unlikely(task == NULL)) {
+		if (*pseq == NULL) {
+			accel_sequence_put(seq);
+		}
+
+		return -ENOMEM;
+	}
+
+	task->crypto_key = key;
+	task->src_domain = src_domain;
+	task->src_domain_ctx = src_domain_ctx;
+	task->s.iovs = src_iovs;
+	task->s.iovcnt = src_iovcnt;
+	task->dst_domain = dst_domain;
+	task->dst_domain_ctx = dst_domain_ctx;
+	task->d.iovs = dst_iovs;
+	task->d.iovcnt = dst_iovcnt;
+	task->iv = iv;
+	task->block_size = block_size;
+	task->flags = flags;
+	task->op_code = ACCEL_OPC_DECRYPT;
+
+	TAILQ_INSERT_TAIL(&seq->tasks, task, seq_link);
+	*pseq = seq;
+
+	return 0;
+}
+
 int
 spdk_accel_get_buf(struct spdk_io_channel *ch, uint64_t len, void **buf,
 		   struct spdk_memory_domain **domain, void **domain_ctx)
@@ -1461,7 +1573,9 @@ accel_sequence_merge_tasks(struct spdk_accel_sequence *seq, struct spdk_accel_ta
 		 * So, for the sake of simplicity, skip this type of operations for now.
 		 */
 		if (next->op_code != ACCEL_OPC_DECOMPRESS &&
-		    next->op_code != ACCEL_OPC_COPY) {
+		    next->op_code != ACCEL_OPC_COPY &&
+		    next->op_code != ACCEL_OPC_ENCRYPT &&
+		    next->op_code != ACCEL_OPC_DECRYPT) {
 			break;
 		}
 		if (task->dst_domain != next->src_domain) {
@@ -1479,6 +1593,8 @@ accel_sequence_merge_tasks(struct spdk_accel_sequence *seq, struct spdk_accel_ta
 		break;
 	case ACCEL_OPC_DECOMPRESS:
 	case ACCEL_OPC_FILL:
+	case ACCEL_OPC_ENCRYPT:
+	case ACCEL_OPC_DECRYPT:
 		/* We can only merge tasks when one of them is a copy */
 		if (next->op_code != ACCEL_OPC_COPY) {
 			break;
diff --git a/lib/accel/spdk_accel.map b/lib/accel/spdk_accel.map
index 2c964b4c6..0c053d3c2 100644
--- a/lib/accel/spdk_accel.map
+++ b/lib/accel/spdk_accel.map
@@ -23,6 +23,8 @@
 	spdk_accel_append_copy;
 	spdk_accel_append_fill;
 	spdk_accel_append_decompress;
+	spdk_accel_append_encrypt;
+	spdk_accel_append_decrypt;
 	spdk_accel_sequence_finish;
 	spdk_accel_sequence_abort;
 	spdk_accel_sequence_reverse;
diff --git a/test/unit/lib/accel/accel.c/accel_ut.c b/test/unit/lib/accel/accel.c/accel_ut.c
index 4b550dc80..3bf0d3fff 100644
--- a/test/unit/lib/accel/accel.c/accel_ut.c
+++ b/test/unit/lib/accel/accel.c/accel_ut.c
@@ -1463,6 +1463,7 @@ test_sequence_copy_elision(void)
 	struct iovec src_iovs[4], dst_iovs[4], exp_iovs[2];
 	char buf[4096], tmp[4][4096];
 	struct accel_module modules[ACCEL_OPC_LAST];
+	struct spdk_accel_crypto_key key = {};
 	int i, rc, completed;
 
 	ioch = spdk_accel_get_io_channel();
@@ -1750,6 +1751,112 @@ test_sequence_copy_elision(void)
 	CU_ASSERT_EQUAL(g_seq_operations[ACCEL_OPC_COPY].count, 0);
 	CU_ASSERT_EQUAL(g_seq_operations[ACCEL_OPC_FILL].count, 1);
 
+	/* Check copy + encrypt + copy */
+	seq = NULL;
+	completed = 0;
+	g_seq_operations[ACCEL_OPC_COPY].count = 0;
+	g_seq_operations[ACCEL_OPC_ENCRYPT].count = 0;
+	g_seq_operations[ACCEL_OPC_ENCRYPT].dst_iovcnt = 1;
+	g_seq_operations[ACCEL_OPC_ENCRYPT].src_iovcnt = 1;
+	g_seq_operations[ACCEL_OPC_ENCRYPT].src_iovs = &exp_iovs[0];
+	g_seq_operations[ACCEL_OPC_ENCRYPT].dst_iovs = &exp_iovs[1];
+	exp_iovs[0].iov_base = tmp[0];
+	exp_iovs[0].iov_len = sizeof(tmp[0]);
+	exp_iovs[1].iov_base = buf;
+	exp_iovs[1].iov_len = sizeof(buf);
+
+	dst_iovs[0].iov_base = tmp[1];
+	dst_iovs[0].iov_len = sizeof(tmp[1]);
+	src_iovs[0].iov_base = tmp[0];
+	src_iovs[0].iov_len = sizeof(tmp[0]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[0], 1, NULL, NULL,
+				    &src_iovs[0], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[1].iov_base = tmp[2];
+	dst_iovs[1].iov_len = sizeof(tmp[2]);
+	src_iovs[1].iov_base = tmp[1];
+	src_iovs[1].iov_len = sizeof(tmp[1]);
+	rc = spdk_accel_append_encrypt(&seq, ioch, &key, &dst_iovs[1], 1, NULL, NULL,
+				       &src_iovs[1], 1, NULL, NULL, 0, sizeof(tmp[2]), 0,
+				       ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[2].iov_base = buf;
+	dst_iovs[2].iov_len = sizeof(buf);
+	src_iovs[2].iov_base = tmp[2];
+	src_iovs[2].iov_len = sizeof(tmp[2]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[2], 1, NULL, NULL,
+				    &src_iovs[2], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	ut_seq.complete = false;
+	rc = spdk_accel_sequence_finish(seq, ut_sequence_complete_cb, &ut_seq);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	poll_threads();
+
+	CU_ASSERT_EQUAL(completed, 3);
+	CU_ASSERT(ut_seq.complete);
+	CU_ASSERT_EQUAL(ut_seq.status, 0);
+	CU_ASSERT_EQUAL(g_seq_operations[ACCEL_OPC_COPY].count, 0);
+	CU_ASSERT_EQUAL(g_seq_operations[ACCEL_OPC_ENCRYPT].count, 1);
+
+	/* Check copy + decrypt + copy */
+	seq = NULL;
+	completed = 0;
+	g_seq_operations[ACCEL_OPC_COPY].count = 0;
+	g_seq_operations[ACCEL_OPC_DECRYPT].count = 0;
+	g_seq_operations[ACCEL_OPC_DECRYPT].dst_iovcnt = 1;
+	g_seq_operations[ACCEL_OPC_DECRYPT].src_iovcnt = 1;
+	g_seq_operations[ACCEL_OPC_DECRYPT].src_iovs = &exp_iovs[0];
+	g_seq_operations[ACCEL_OPC_DECRYPT].dst_iovs = &exp_iovs[1];
+	exp_iovs[0].iov_base = tmp[0];
+	exp_iovs[0].iov_len = sizeof(tmp[0]);
+	exp_iovs[1].iov_base = buf;
+	exp_iovs[1].iov_len = sizeof(buf);
+
+	dst_iovs[0].iov_base = tmp[1];
+	dst_iovs[0].iov_len = sizeof(tmp[1]);
+	src_iovs[0].iov_base = tmp[0];
+	src_iovs[0].iov_len = sizeof(tmp[0]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[0], 1, NULL, NULL,
+				    &src_iovs[0], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[1].iov_base = tmp[2];
+	dst_iovs[1].iov_len = sizeof(tmp[2]);
+	src_iovs[1].iov_base = tmp[1];
+	src_iovs[1].iov_len = sizeof(tmp[1]);
+	rc = spdk_accel_append_decrypt(&seq, ioch, &key, &dst_iovs[1], 1, NULL, NULL,
+				       &src_iovs[1], 1, NULL, NULL, 0, sizeof(tmp[2]), 0,
+				       ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[2].iov_base = buf;
+	dst_iovs[2].iov_len = sizeof(buf);
+	src_iovs[2].iov_base = tmp[2];
+	src_iovs[2].iov_len = sizeof(tmp[2]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[2], 1, NULL, NULL,
+				    &src_iovs[2], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	ut_seq.complete = false;
+	rc = spdk_accel_sequence_finish(seq, ut_sequence_complete_cb, &ut_seq);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	poll_threads();
+
+	CU_ASSERT_EQUAL(completed, 3);
+	CU_ASSERT(ut_seq.complete);
+	CU_ASSERT_EQUAL(ut_seq.status, 0);
+	CU_ASSERT_EQUAL(g_seq_operations[ACCEL_OPC_COPY].count, 0);
+	CU_ASSERT_EQUAL(g_seq_operations[ACCEL_OPC_DECRYPT].count, 1);
+
 	/* Cleanup module pointers to make subsequent tests work correctly */
 	for (i = 0; i < ACCEL_OPC_LAST; ++i) {
 		g_modules_opc[i] = modules[i];
@@ -1757,6 +1864,10 @@ test_sequence_copy_elision(void)
 
 	g_seq_operations[ACCEL_OPC_DECOMPRESS].src_iovs = NULL;
 	g_seq_operations[ACCEL_OPC_DECOMPRESS].dst_iovs = NULL;
+	g_seq_operations[ACCEL_OPC_ENCRYPT].src_iovs = NULL;
+	g_seq_operations[ACCEL_OPC_ENCRYPT].src_iovs = NULL;
+	g_seq_operations[ACCEL_OPC_DECRYPT].dst_iovs = NULL;
+	g_seq_operations[ACCEL_OPC_DECRYPT].dst_iovs = NULL;
 
 	spdk_put_io_channel(ioch);
 	poll_threads();
@@ -2784,6 +2895,204 @@ test_sequence_module_memory_domain(void)
 	poll_threads();
 }
 
+#ifdef SPDK_CONFIG_ISAL_CRYPTO
+static void
+ut_encrypt_cb(void *cb_arg, int status)
+{
+	int *completed = cb_arg;
+
+	CU_ASSERT_EQUAL(status, 0);
+
+	*completed = 1;
+}
+
+static void
+test_sequence_crypto(void)
+{
+	struct spdk_accel_sequence *seq = NULL;
+	struct spdk_io_channel *ioch;
+	struct spdk_accel_crypto_key *key;
+	struct spdk_accel_crypto_key_create_param key_params = {
+		.cipher = "AES_XTS",
+		.hex_key = "00112233445566778899aabbccddeeff",
+		.hex_key2 = "ffeeddccbbaa99887766554433221100",
+		.key_name = "ut_key",
+	};
+	struct ut_sequence ut_seq;
+	unsigned char buf[4096], encrypted[4096] = {}, data[4096], tmp[3][4096];
+	struct iovec src_iovs[4], dst_iovs[4];
+	int rc, completed = 0;
+	size_t i;
+
+	ioch = spdk_accel_get_io_channel();
+	SPDK_CU_ASSERT_FATAL(ioch != NULL);
+
+	rc = spdk_accel_crypto_key_create(&key_params);
+	CU_ASSERT_EQUAL(rc, 0);
+	key = spdk_accel_crypto_key_get(key_params.key_name);
+	SPDK_CU_ASSERT_FATAL(key != NULL);
+
+	for (i = 0; i < sizeof(data); ++i) {
+		data[i] = (uint8_t)i & 0xff;
+	}
+
+	dst_iovs[0].iov_base = encrypted;
+	dst_iovs[0].iov_len = sizeof(encrypted);
+	src_iovs[0].iov_base = data;
+	src_iovs[0].iov_len = sizeof(data);
+	rc = spdk_accel_submit_encrypt(ioch, key, &dst_iovs[0], 1, &src_iovs[0], 1, 0, 4096, 0,
+				       ut_encrypt_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	while (!completed) {
+		poll_threads();
+	}
+
+	/* Verify that encryption operation in a sequence produces the same result */
+	seq = NULL;
+	completed = 0;
+
+	dst_iovs[0].iov_base = tmp[0];
+	dst_iovs[0].iov_len = sizeof(tmp[0]);
+	src_iovs[0].iov_base = data;
+	src_iovs[0].iov_len = sizeof(data);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[0], 1, NULL, NULL,
+				    &src_iovs[0], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[1].iov_base = tmp[1];
+	dst_iovs[1].iov_len = sizeof(tmp[1]);
+	src_iovs[1].iov_base = tmp[0];
+	src_iovs[1].iov_len = sizeof(tmp[0]);
+	rc = spdk_accel_append_encrypt(&seq, ioch, key, &dst_iovs[1], 1, NULL, NULL,
+				       &src_iovs[1], 1, NULL, NULL, 0, 4096, 0,
+				       ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[2].iov_base = buf;
+	dst_iovs[2].iov_len = sizeof(buf);
+	src_iovs[2].iov_base = tmp[1];
+	src_iovs[2].iov_len = sizeof(tmp[1]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[2], 1, NULL, NULL,
+				    &src_iovs[2], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	ut_seq.complete = false;
+	rc = spdk_accel_sequence_finish(seq, ut_sequence_complete_cb, &ut_seq);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	poll_threads();
+
+	CU_ASSERT_EQUAL(completed, 3);
+	CU_ASSERT(ut_seq.complete);
+	CU_ASSERT_EQUAL(ut_seq.status, 0);
+	CU_ASSERT_EQUAL(memcmp(buf, encrypted, sizeof(buf)), 0);
+
+	/* Check that decryption produces the original buffer */
+	seq = NULL;
+	completed = 0;
+	memset(buf, 0, sizeof(buf));
+
+	dst_iovs[0].iov_base = tmp[0];
+	dst_iovs[0].iov_len = sizeof(tmp[0]);
+	src_iovs[0].iov_base = encrypted;
+	src_iovs[0].iov_len = sizeof(encrypted);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[0], 1, NULL, NULL,
+				    &src_iovs[0], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[1].iov_base = tmp[1];
+	dst_iovs[1].iov_len = sizeof(tmp[1]);
+	src_iovs[1].iov_base = tmp[0];
+	src_iovs[1].iov_len = sizeof(tmp[0]);
+	rc = spdk_accel_append_decrypt(&seq, ioch, key, &dst_iovs[1], 1, NULL, NULL,
+				       &src_iovs[1], 1, NULL, NULL, 0, 4096, 0,
+				       ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[2].iov_base = buf;
+	dst_iovs[2].iov_len = sizeof(buf);
+	src_iovs[2].iov_base = tmp[1];
+	src_iovs[2].iov_len = sizeof(tmp[1]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[2], 1, NULL, NULL,
+				    &src_iovs[2], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	ut_seq.complete = false;
+	rc = spdk_accel_sequence_finish(seq, ut_sequence_complete_cb, &ut_seq);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	poll_threads();
+
+	CU_ASSERT_EQUAL(completed, 3);
+	CU_ASSERT(ut_seq.complete);
+	CU_ASSERT_EQUAL(ut_seq.status, 0);
+	CU_ASSERT_EQUAL(memcmp(buf, data, sizeof(buf)), 0);
+
+	/* Check encrypt + decrypt in a single sequence */
+	seq = NULL;
+	completed = 0;
+	memset(buf, 0, sizeof(buf));
+
+	dst_iovs[0].iov_base = tmp[0];
+	dst_iovs[0].iov_len = sizeof(tmp[0]);
+	src_iovs[0].iov_base = data;
+	src_iovs[0].iov_len = sizeof(data);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[0], 1, NULL, NULL,
+				    &src_iovs[0], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[1].iov_base = tmp[1];
+	dst_iovs[1].iov_len = sizeof(tmp[1]);
+	src_iovs[1].iov_base = tmp[0];
+	src_iovs[1].iov_len = sizeof(tmp[0]);
+	rc = spdk_accel_append_encrypt(&seq, ioch, key, &dst_iovs[1], 1, NULL, NULL,
+				       &src_iovs[1], 1, NULL, NULL, 0, 4096, 0,
+				       ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+
+	dst_iovs[2].iov_base = tmp[2];
+	dst_iovs[2].iov_len = sizeof(tmp[2]);
+	src_iovs[2].iov_base = tmp[1];
+	src_iovs[2].iov_len = sizeof(tmp[1]);
+	rc = spdk_accel_append_decrypt(&seq, ioch, key, &dst_iovs[2], 1, NULL, NULL,
+				       &src_iovs[2], 1, NULL, NULL, 0, 4096, 0,
+				       ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	dst_iovs[3].iov_base = buf;
+	dst_iovs[3].iov_len = sizeof(buf);
+	src_iovs[3].iov_base = tmp[2];
+	src_iovs[3].iov_len = sizeof(tmp[2]);
+	rc = spdk_accel_append_copy(&seq, ioch, &dst_iovs[3], 1, NULL, NULL,
+				    &src_iovs[3], 1, NULL, NULL, 0,
+				    ut_sequence_step_cb, &completed);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	ut_seq.complete = false;
+	rc = spdk_accel_sequence_finish(seq, ut_sequence_complete_cb, &ut_seq);
+	CU_ASSERT_EQUAL(rc, 0);
+
+	poll_threads();
+
+	CU_ASSERT_EQUAL(completed, 4);
+	CU_ASSERT(ut_seq.complete);
+	CU_ASSERT_EQUAL(ut_seq.status, 0);
+	CU_ASSERT_EQUAL(memcmp(buf, data, sizeof(buf)), 0);
+
+	rc = spdk_accel_crypto_key_destroy(key);
+	CU_ASSERT_EQUAL(rc, 0);
+	spdk_put_io_channel(ioch);
+	poll_threads();
+}
+#endif /* SPDK_CONFIG_ISAL_CRYPTO */
+
 static int
 test_sequence_setup(void)
 {
@@ -2865,7 +3174,9 @@ main(int argc, char **argv)
 	CU_ADD_TEST(seq_suite, test_sequence_accel_buffers);
 	CU_ADD_TEST(seq_suite, test_sequence_memory_domain);
 	CU_ADD_TEST(seq_suite, test_sequence_module_memory_domain);
-
+#ifdef SPDK_CONFIG_ISAL_CRYPTO /* accel_sw requires isa-l-crypto for crypto operations */
+	CU_ADD_TEST(seq_suite, test_sequence_crypto);
+#endif
 	suite = CU_add_suite("accel", test_setup, test_cleanup);
 	CU_ADD_TEST(suite, test_spdk_accel_task_complete);
 	CU_ADD_TEST(suite, test_get_task);