diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6fa0674a3..3009ea469 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -67,6 +67,11 @@ New API `spdk_bdev_part_construct_ext` is added and allows the bdev's UUID to be
 the existing worker and namespace association logic to access every namespace from each worker.
 This replicates behavior of bdevperf application when `-C` option is provided.
 
+### util
+
+New APIs `spdk_uuid_is_null` and `spdk_uuid_set_null` were added to compare and
+set UUID to NULL value.
+
 ## v23.01
 
 ### accel
diff --git a/include/spdk/uuid.h b/include/spdk/uuid.h
index 7dead6f3e..8923029d3 100644
--- a/include/spdk/uuid.h
+++ b/include/spdk/uuid.h
@@ -86,6 +86,22 @@ int spdk_uuid_generate_sha1(struct spdk_uuid *uuid, struct spdk_uuid *ns_uuid, c
  */
 void spdk_uuid_copy(struct spdk_uuid *dst, const struct spdk_uuid *src);
 
+/**
+ * Compare the UUID to the NULL value (all bits equal to zero).
+ *
+ * \param uuid The UUID to test.
+ *
+ * \return true if uuid is equal to the NULL value, false if not.
+ */
+bool spdk_uuid_is_null(const struct spdk_uuid *uuid);
+
+/**
+ * Set the value of UUID to the NULL value.
+ *
+ * \param uuid The UUID to set.
+ */
+void spdk_uuid_set_null(struct spdk_uuid *uuid);
+
 #ifdef __cplusplus
 }
 #endif
diff --git a/lib/bdev/bdev.c b/lib/bdev/bdev.c
index b342a785a..4e3bed7a0 100644
--- a/lib/bdev/bdev.c
+++ b/lib/bdev/bdev.c
@@ -7427,7 +7427,7 @@ bdev_register(struct spdk_bdev *bdev)
 
 	/* UUID may be specified by the user or defined by bdev itself.
 	 * Otherwise it will be generated here, so this field will never be empty. */
-	if (spdk_mem_all_zero(&bdev->uuid, sizeof(bdev->uuid))) {
+	if (spdk_uuid_is_null(&bdev->uuid)) {
 		spdk_uuid_generate(&bdev->uuid);
 	}
 
diff --git a/lib/lvol/lvol.c b/lib/lvol/lvol.c
index 0b552d16a..fcf5beb24 100644
--- a/lib/lvol/lvol.c
+++ b/lib/lvol/lvol.c
@@ -255,11 +255,11 @@ load_next_lvol(void *cb_arg, struct spdk_blob *blob, int lvolerrno)
 	if (rc != 0 || value_len != SPDK_UUID_STRING_LEN || attr[SPDK_UUID_STRING_LEN - 1] != '\0' ||
 	    spdk_uuid_parse(&lvol->uuid, attr) != 0) {
 		SPDK_INFOLOG(lvol, "Missing or corrupt lvol uuid\n");
-		memset(&lvol->uuid, 0, sizeof(lvol->uuid));
+		spdk_uuid_set_null(&lvol->uuid);
 	}
 	spdk_uuid_fmt_lower(lvol->uuid_str, sizeof(lvol->uuid_str), &lvol->uuid);
 
-	if (!spdk_mem_all_zero(&lvol->uuid, sizeof(lvol->uuid))) {
+	if (!spdk_uuid_is_null(&lvol->uuid)) {
 		snprintf(lvol->unique_id, sizeof(lvol->unique_id), "%s", lvol->uuid_str);
 	} else {
 		spdk_uuid_fmt_lower(lvol->unique_id, sizeof(lvol->unique_id), &lvol->lvol_store->uuid);
diff --git a/lib/nvmf/nvmf.c b/lib/nvmf/nvmf.c
index 6cc1408dd..c03242a3e 100644
--- a/lib/nvmf/nvmf.c
+++ b/lib/nvmf/nvmf.c
@@ -544,7 +544,7 @@ nvmf_write_subsystem_config_json(struct spdk_json_write_ctx *w,
 			spdk_json_write_named_string_fmt(w, "eui64", "%016"PRIX64, from_be64(&ns_opts.eui64));
 		}
 
-		if (!spdk_mem_all_zero(&ns_opts.uuid, sizeof(ns_opts.uuid))) {
+		if (!spdk_uuid_is_null(&ns_opts.uuid)) {
 			spdk_uuid_fmt_lower(uuid_str, sizeof(uuid_str), &ns_opts.uuid);
 			spdk_json_write_named_string(w, "uuid",  uuid_str);
 		}
diff --git a/lib/nvmf/nvmf_rpc.c b/lib/nvmf/nvmf_rpc.c
index c69af44ca..3039a4e91 100644
--- a/lib/nvmf/nvmf_rpc.c
+++ b/lib/nvmf/nvmf_rpc.c
@@ -259,7 +259,7 @@ dump_nvmf_subsystem(struct spdk_json_write_ctx *w, struct spdk_nvmf_subsystem *s
 				json_write_hex_str(w, ns_opts.eui64, sizeof(ns_opts.eui64));
 			}
 
-			if (!spdk_mem_all_zero(&ns_opts.uuid, sizeof(ns_opts.uuid))) {
+			if (!spdk_uuid_is_null(&ns_opts.uuid)) {
 				char uuid_str[SPDK_UUID_STRING_LEN];
 
 				spdk_uuid_fmt_lower(uuid_str, sizeof(uuid_str), &ns_opts.uuid);
@@ -1221,7 +1221,7 @@ nvmf_rpc_ns_paused(struct spdk_nvmf_subsystem *subsystem,
 	SPDK_STATIC_ASSERT(sizeof(ns_opts.eui64) == sizeof(ctx->ns_params.eui64), "size mismatch");
 	memcpy(ns_opts.eui64, ctx->ns_params.eui64, sizeof(ns_opts.eui64));
 
-	if (!spdk_mem_all_zero(&ctx->ns_params.uuid, sizeof(ctx->ns_params.uuid))) {
+	if (!spdk_uuid_is_null(&ctx->ns_params.uuid)) {
 		ns_opts.uuid = ctx->ns_params.uuid;
 	}
 
diff --git a/lib/nvmf/subsystem.c b/lib/nvmf/subsystem.c
index 36c58962d..eaa8a52c1 100644
--- a/lib/nvmf/subsystem.c
+++ b/lib/nvmf/subsystem.c
@@ -1529,7 +1529,7 @@ spdk_nvmf_ns_opts_get_defaults(struct spdk_nvmf_ns_opts *opts, size_t opts_size)
 		memset(opts->eui64, 0, sizeof(opts->eui64));
 	}
 	if (FIELD_OK(uuid)) {
-		memset(&opts->uuid, 0, sizeof(opts->uuid));
+		spdk_uuid_set_null(&opts->uuid);
 	}
 	SET_FIELD(anagrpid, 0);
 
@@ -1558,7 +1558,7 @@ nvmf_ns_opts_copy(struct spdk_nvmf_ns_opts *opts,
 		memcpy(opts->eui64, user_opts->eui64, sizeof(opts->eui64));
 	}
 	if (FIELD_OK(uuid)) {
-		memcpy(&opts->uuid, &user_opts->uuid, sizeof(opts->uuid));
+		spdk_uuid_copy(&opts->uuid, &user_opts->uuid);
 	}
 	SET_FIELD(anagrpid);
 
@@ -1686,7 +1686,7 @@ spdk_nvmf_subsystem_add_ns_ext(struct spdk_nvmf_subsystem *subsystem, const char
 	/* Cache the zcopy capability of the bdev device */
 	ns->zcopy = spdk_bdev_io_type_supported(ns->bdev, SPDK_BDEV_IO_TYPE_ZCOPY);
 
-	if (spdk_mem_all_zero(&opts.uuid, sizeof(opts.uuid))) {
+	if (spdk_uuid_is_null(&opts.uuid)) {
 		opts.uuid = *spdk_bdev_get_uuid(ns->bdev);
 	}
 
diff --git a/lib/reduce/reduce.c b/lib/reduce/reduce.c
index 25abbc649..f367cabaa 100644
--- a/lib/reduce/reduce.c
+++ b/lib/reduce/reduce.c
@@ -621,7 +621,7 @@ spdk_reduce_vol_init(struct spdk_reduce_vol_params *params,
 		return;
 	}
 
-	if (spdk_mem_all_zero(&params->uuid, sizeof(params->uuid))) {
+	if (spdk_uuid_is_null(&params->uuid)) {
 		spdk_uuid_generate(&params->uuid);
 	}
 
diff --git a/lib/util/spdk_util.map b/lib/util/spdk_util.map
index 97ebdca52..3e4eec8ae 100644
--- a/lib/util/spdk_util.map
+++ b/lib/util/spdk_util.map
@@ -155,6 +155,8 @@
 	spdk_uuid_generate;
 	spdk_uuid_generate_sha1;
 	spdk_uuid_copy;
+	spdk_uuid_is_null;
+	spdk_uuid_set_null;
 
 	# public functions in fd_group.h
 	spdk_fd_group_create;
diff --git a/lib/util/uuid.c b/lib/util/uuid.c
index 60b6e679f..96ddf6fbd 100644
--- a/lib/util/uuid.c
+++ b/lib/util/uuid.c
@@ -52,6 +52,18 @@ spdk_uuid_copy(struct spdk_uuid *dst, const struct spdk_uuid *src)
 	uuid_copy((void *)dst, (void *)src);
 }
 
+bool
+spdk_uuid_is_null(const struct spdk_uuid *uuid)
+{
+	return uuid_is_null((void *)uuid);
+}
+
+void
+spdk_uuid_set_null(struct spdk_uuid *uuid)
+{
+	uuid_clear((void *)uuid);
+}
+
 #else
 
 #include <uuid.h>
@@ -108,6 +120,18 @@ spdk_uuid_copy(struct spdk_uuid *dst, const struct spdk_uuid *src)
 	memcpy(dst, src, sizeof(*dst));
 }
 
+bool
+spdk_uuid_is_null(const struct spdk_uuid *uuid)
+{
+	return uuid_is_nil((const uuid_t *)uuid, NULL);
+}
+
+void
+spdk_uuid_set_null(struct spdk_uuid *uuid)
+{
+	uuid_create_nil((uuid_t *)uuid, NULL);
+}
+
 #endif
 
 int
diff --git a/module/bdev/ftl/bdev_ftl_rpc.c b/module/bdev/ftl/bdev_ftl_rpc.c
index 83e55d467..9c6d0ccfd 100644
--- a/module/bdev/ftl/bdev_ftl_rpc.c
+++ b/module/bdev/ftl/bdev_ftl_rpc.c
@@ -93,7 +93,7 @@ rpc_bdev_ftl_create(struct spdk_jsonrpc_request *request,
 		goto out;
 	}
 
-	if (spdk_mem_all_zero(&conf.uuid, sizeof(conf.uuid))) {
+	if (spdk_uuid_is_null(&conf.uuid)) {
 		conf.mode |= SPDK_FTL_MODE_CREATE;
 	}
 
diff --git a/module/bdev/malloc/bdev_malloc.c b/module/bdev/malloc/bdev_malloc.c
index 7da754ddc..1bbc90f59 100644
--- a/module/bdev/malloc/bdev_malloc.c
+++ b/module/bdev/malloc/bdev_malloc.c
@@ -737,7 +737,7 @@ create_malloc_disk(struct spdk_bdev **bdev, const struct malloc_bdev_opts *opts)
 		mdisk->disk.optimal_io_boundary = opts->optimal_io_boundary;
 		mdisk->disk.split_on_optimal_io_boundary = true;
 	}
-	if (!spdk_mem_all_zero(&opts->uuid, sizeof(opts->uuid))) {
+	if (!spdk_uuid_is_null(&opts->uuid)) {
 		spdk_uuid_copy(&mdisk->disk.uuid, &opts->uuid);
 	}
 
diff --git a/test/unit/lib/bdev/bdev.c/bdev_ut.c b/test/unit/lib/bdev/bdev.c/bdev_ut.c
index d1452f859..254bafcec 100644
--- a/test/unit/lib/bdev/bdev.c/bdev_ut.c
+++ b/test/unit/lib/bdev/bdev.c/bdev_ut.c
@@ -5943,7 +5943,7 @@ bdev_register_uuid_alias(void)
 	bdev = allocate_bdev("bdev0");
 
 	/* Make sure an UUID was generated  */
-	CU_ASSERT_FALSE(spdk_mem_all_zero(&bdev->uuid, sizeof(bdev->uuid)));
+	CU_ASSERT_FALSE(spdk_uuid_is_null(&bdev->uuid));
 
 	/* Check that an UUID alias was registered */
 	spdk_uuid_fmt_lower(uuid, sizeof(uuid), &bdev->uuid);
diff --git a/test/unit/lib/nvmf/ctrlr.c/ctrlr_ut.c b/test/unit/lib/nvmf/ctrlr.c/ctrlr_ut.c
index b699b2249..5d5842453 100644
--- a/test/unit/lib/nvmf/ctrlr.c/ctrlr_ut.c
+++ b/test/unit/lib/nvmf/ctrlr.c/ctrlr_ut.c
@@ -1361,7 +1361,7 @@ test_reservation_write_exclusive(void)
 	SPDK_CU_ASSERT_FATAL(rc == 0);
 
 	/* Unregister Host C */
-	memset(&g_ns_info.reg_hostid[2], 0, sizeof(struct spdk_uuid));
+	spdk_uuid_set_null(&g_ns_info.reg_hostid[2]);
 
 	/* Test Case: Read and Write commands from non-registrant Host C */
 	cmd.nvme_cmd.opc = SPDK_NVME_OPC_WRITE;
@@ -1430,7 +1430,7 @@ _test_reservation_write_exclusive_regs_only_and_all_regs(enum spdk_nvme_reservat
 	SPDK_CU_ASSERT_FATAL(rc == 0);
 
 	/* Unregister Host C */
-	memset(&g_ns_info.reg_hostid[2], 0, sizeof(struct spdk_uuid));
+	spdk_uuid_set_null(&g_ns_info.reg_hostid[2]);
 
 	/* Test Case: Read and Write commands from non-registrant Host C */
 	cmd.nvme_cmd.opc = SPDK_NVME_OPC_READ;
@@ -1472,7 +1472,7 @@ _test_reservation_exclusive_access_regs_only_and_all_regs(enum spdk_nvme_reserva
 	SPDK_CU_ASSERT_FATAL(rc == 0);
 
 	/* Unregister Host B */
-	memset(&g_ns_info.reg_hostid[1], 0, sizeof(struct spdk_uuid));
+	spdk_uuid_set_null(&g_ns_info.reg_hostid[1]);
 
 	/* Test Case: Issue a Read command from Host B */
 	cmd.nvme_cmd.opc = SPDK_NVME_OPC_READ;