diff --git a/lib/vhost/rte_vhost_user.c b/lib/vhost/rte_vhost_user.c
index eae22895c..be3f711f8 100644
--- a/lib/vhost/rte_vhost_user.c
+++ b/lib/vhost/rte_vhost_user.c
@@ -351,6 +351,14 @@ int
 vhost_vq_used_signal(struct spdk_vhost_session *vsession,
 		     struct spdk_vhost_virtqueue *virtqueue)
 {
+	/* The flag is true when DPDK "vhost-events" thread is holding all
+	 * VQ's access lock, we will skip to post IRQs this round poll, and
+	 * try to post IRQs in next poll or after starting the device again.
+	 */
+	if (spdk_unlikely(vsession->skip_used_signal)) {
+		return 0;
+	}
+
 	if (virtqueue->used_req_cnt == 0) {
 		return 0;
 	}
@@ -1408,6 +1416,13 @@ extern_vhost_pre_msg_handler(int vid, void *_msg)
 	case VHOST_USER_SET_VRING_BASE:
 	case VHOST_USER_SET_VRING_ADDR:
 	case VHOST_USER_SET_VRING_NUM:
+		/* For vhost-user socket messages except VHOST_USER_GET_VRING_BASE,
+		 * rte_vhost holds all VQ's access lock, then after DPDK 22.07 release,
+		 * `rte_vhost_vring_call` also needs to hold VQ's access lock, so we
+		 * can't call this function in DPDK "vhost-events" thread context, here
+		 * SPDK vring poller will avoid executing this function when it's TRUE.
+		 */
+		vsession->skip_used_signal = true;
 		if (vsession->forced_polling && vsession->started) {
 			/* Additional queues are being initialized, so we either processed
 			 * enough I/Os and are switching from SeaBIOS to the OS now, or
@@ -1435,6 +1450,7 @@ extern_vhost_pre_msg_handler(int vid, void *_msg)
 		 * rte_vhost.
 		 */
 	case VHOST_USER_SET_MEM_TABLE:
+		vsession->skip_used_signal = true;
 		/* rte_vhost will unmap previous memory that SPDK may still
 		 * have pending DMA operations on. We can't let that happen,
 		 * so stop the device before letting rte_vhost unmap anything.
@@ -1479,6 +1495,7 @@ extern_vhost_pre_msg_handler(int vid, void *_msg)
 		break;
 	}
 
+	vsession->skip_used_signal = false;
 	return RTE_VHOST_MSG_RESULT_NOT_HANDLED;
 }
 
diff --git a/lib/vhost/vhost_internal.h b/lib/vhost/vhost_internal.h
index f0aa0b198..8a1f1ea61 100644
--- a/lib/vhost/vhost_internal.h
+++ b/lib/vhost/vhost_internal.h
@@ -119,6 +119,7 @@ struct spdk_vhost_session {
 	bool needs_restart;
 	bool forced_polling;
 	bool interrupt_mode;
+	bool skip_used_signal;
 
 	struct rte_vhost_memory *mem;