diff --git a/lib/vhost/rte_vhost/vhost_user.c b/lib/vhost/rte_vhost/vhost_user.c
index 2acf08849..9aef88c9b 100644
--- a/lib/vhost/rte_vhost/vhost_user.c
+++ b/lib/vhost/rte_vhost/vhost_user.c
@@ -584,6 +584,7 @@ vhost_setup_mem_table(struct virtio_net *dev)
 {
 	struct VhostUserMemory memory = dev->mem_table;
 	struct rte_vhost_mem_region *reg;
+	struct vhost_virtqueue *vq;
 	void *mmap_addr;
 	uint64_t mmap_size;
 	uint64_t mmap_offset;
@@ -597,6 +598,17 @@ vhost_setup_mem_table(struct virtio_net *dev)
 		dev->mem = NULL;
 	}
 
+	for (i = 0; i < dev->nr_vring; i++) {
+		vq = dev->virtqueue[i];
+		/* Those addresses won't be valid anymore in host address space
+		 * after setting new mem table. Initiator need to resend these
+		 * addresses.
+		 */
+		vq->desc = NULL;
+		vq->avail = NULL;
+		vq->used = NULL;
+	}
+
 	dev->nr_guest_pages = 0;
 	if (!dev->guest_pages) {
 		dev->max_guest_pages = 8;