diff --git a/lib/env_dpdk/pci.c b/lib/env_dpdk/pci.c
index 2e9d4070c..5cfa63619 100644
--- a/lib/env_dpdk/pci.c
+++ b/lib/env_dpdk/pci.c
@@ -176,6 +176,12 @@ spdk_pci_driver_register(struct spdk_pci_driver *driver)
 }
 
 #if RTE_VERSION >= RTE_VERSION_NUM(18, 5, 0, 0)
+static void
+spdk_pci_device_rte_hotremove_cb(void *dev)
+{
+	spdk_detach_rte((struct spdk_pci_device *)dev);
+}
+
 static void
 spdk_pci_device_rte_hotremove(const char *device_name,
 			      enum rte_dev_event_type event,
@@ -191,7 +197,6 @@ spdk_pci_device_rte_hotremove(const char *device_name,
 	pthread_mutex_lock(&g_pci_mutex);
 	TAILQ_FOREACH(dev, &g_pci_devices, internal.tailq) {
 		struct rte_pci_device *rte_dev = dev->dev_handle;
-
 		if (strcmp(rte_dev->name, device_name) == 0 &&
 		    !dev->internal.pending_removal) {
 			can_detach = !dev->internal.attached;
@@ -203,8 +208,17 @@ spdk_pci_device_rte_hotremove(const char *device_name,
 	pthread_mutex_unlock(&g_pci_mutex);
 
 	if (dev != NULL && can_detach) {
-		/* if device is not attached, we can remove it right away. */
-		spdk_detach_rte(dev);
+		/* If device is not attached, we can remove it right away.
+		 *
+		 * Because the user's callback is invoked in eal interrupt
+		 * callback, the interrupt callback need to be finished before
+		 * it can be unregistered when detaching device. So finish
+		 * callback soon and use a deferred removal to detach device
+		 * is need. It is a workaround, once the device detaching be
+		 * moved into the eal in the future, the deferred removal could
+		 * be deleted.
+		 */
+		rte_eal_alarm_set(1, spdk_pci_device_rte_hotremove_cb, dev);
 	}
 }
 #endif